Collocation Of Buprenorphine With HCV Treatment To Improve Adherence And Reduce Harm In PWID With HCV: Update From The ANCHOR Study

Author: Rosenthal ES, Hill K, Nussdorf L, Mathur P, Gross C, Silk R, Akoth E, Sternberg D, Sidique N, Chaudhury C, Masur H, Kottilil S, Kattakuzhy S

Theme: Clinical Research Year: 2018

People who inject drugs (PWID) have increased risk for HCV, however many are required to be
abstinent or on stable medication-assisted treatment (MAT) to receive DAAs. Offering
buprenorphine with DAAs may improve HCV outcomes and reduce harms associated with
injection drug use (IDU).
ANCHOR is a single-center study evaluating treatment of HCV in PWID with chronic HCV,
opioid use disorder (OUD), and IDU within 3 months. Participants receive sofosbuvir/velpatasvir
(SOF/VEL) and optional buprenorphine.
154 patients screened and 90 enrolled. Participants are predominantly male (77%), median 56
years, black (92%) and inject opioids at least daily (60%). 61 (68%) patients were not on MAT at
screening, all of whom reported interest in buprenorphine. To date, 39 (64%) have started
buprenorphine and 26 (66%) are retained on buprenorphine.
Compared to patients on no MAT, patients who started buprenorphine on study were more likely
to attend week 4 and week 12 visits (95% vs 71%; p=0.02; 86% vs 40% p=0.007) and to pick-up
the second bottle of SOF/VEL (100% vs 82%; p=0.02).
Patients who started buprenorphine had a significant decline in Darke HIV-Risk Taking
Behaviour Scale from day0 to week4 (p=0.003), day0 to week12 (p=0.001), and day0 to week24
(p=0.003). No significant change was found in patients on baseline MAT or no MAT.
Data for 100 enrolled patients will be available at the time of INHSU.
Preliminary results of the ANCHOR study support that PWID can successfully initiate
buprenorphine during HCV treatment. Use of buprenorphine improves visit adherence and
decreases risk behavior compared to those not on MAT. We await long-term data to see if
ANCHOR collocated care model can provide a critical opportunity to cure HCV while
simultaneously preventing reinfection, and preventing long-term harm associated with IDU and
Disclosure of Interest Statement:
Gilead Sciences provided investigator initiated grant funding and medication donation for this
study. Dr Rosenthal has institutional research grants from Gilead and Merck . Dr. Kattakuzhy
has institutional research grants from Gilead. Dr. Mathur has an institutional research grant from

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